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The edition · Emergency & Critical Care

Most ICU survivors could drive months before anyone told them so

Four in five were assessed as fit to drive at three months and fewer than half had resumed; a three-marker rapid immunoassay reproduces paediatric critical care subphenotypes at the bedside; and a thousand studies of kidney injury biomarkers have produced twelve on management.

The edition in brief

A UK prospective cohort put 33 intensive care survivors — all ventilated for at least 72 hours or supported with extracorporeal membrane oxygenation — through a full licensing-authority driving assessment at a median 12.5 weeks after discharge. Twenty-six (79%) were judged capable of driving a standard vehicle, but only 15 (45%) had actually resumed. Of the seven found unfit, four had physical and two psychological impairment, and most resumed within the year after adaptation or retraining. Driving confidence rose from a median of 7 to 9 and 97% rated the assessment very good or excellent. A retrospective cohort of 269 critically ill children with acute cardiorespiratory failure and hyperglycaemia showed that a three-marker rapid immunoassay classifier using interleukin-6, interleukin-8 and soluble tumour necrosis factor receptor 1 reproduced latent-class subphenotypes with an area under the curve of 0.90 and 89.6% agreement, preserving the mortality difference (33.3% versus 11.8%) and the differential response to intensive insulin. A systematic evidence map of 1,116 studies of novel acute kidney injury biomarkers found 944 on prediction and only 12 on management. Across 5.37 million weighted US paediatric mental health emergency visits, the odds of presenting to a high-volume paediatric emergency department differed by ethnicity and by diagnosis. A pearl covers the handover of a patient still in the department. The edition closes with a Hong Kong randomised trial in which a brief telephone intervention plus six months of weekly messaging after emergency discharge raised abstinence from a health-risk behaviour from 19.9% to 30.1% at six months, with the effect fading once the messages stopped.

In this edition
01
Clinical update

Four in five intensive care survivors could drive; fewer than half had

Ask about driving at intensive care follow-up — most survivors are able long before they believe they are allowed.

2 min · Critical care medicineRead →
Primary outcome
driving ability on comprehensive assessment at approximately 3 months after discharge
Effect
26 of 33 (79%) capable of driving a standard vehicle; 15 (45%) had resumed
02Clinical update

A thousand studies of kidney injury biomarkers, and twelve on what to do with the result

Reserve novel kidney injury biomarkers for surveillance in surgical or nephrotoxin-exposed patients, where implementation evidence actually exists.

2 min · Critical care medicineRead →
03Research

Three markers on a rapid platform reproduced critical care subphenotypes

Subphenotyping is becoming operationally feasible, but the classifier has to be rebuilt on whichever assay your laboratory runs.

2 min · Critical care medicineRead →
04Research

Which emergency department a child reaches in crisis varied by ethnicity and diagnosis

Find out now what your department can offer a child in mental health crisis, rather than at three in the morning.

2 min · Annals of emergency medicineRead →
05Pearl

Hand over what you are worried about, not what you have done

Lead the handover with what is worrying you and what would confirm it — a complete summary with no concern in it reads as reassurance.

1 minRead →
06
Practice changer

A phone call and six months of messages after discharge changed behaviour — while the messages lasted

Structured telephone follow-up plus regular messaging after emergency discharge changes behaviour, but only for as long as you keep sending it.

2 min · PLoS medicineRead →
Primary outcome
self-reported abstinence from at least one health-risk behaviour at 6 months
Effect
30.1% vs 19.9%, risk ratio 1.51 (95% CI 1.13–2.02), p=0.006

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