Emergency & Critical Care · page 3

Two large emergency trials found statistically significant pain differences that fall below what patients notice

Magnesium added to paracetamol raised headache treatment success from 65.1% to 78.9%, and intranasal ketamine beat subcutaneous by 0.72 points — both statistically clear, both under the 1.3-point threshold for clinical importance. What separates them is rescue analgesia and route, not analgesia itself.