The edition · Internal Medicine
Simple prompts raised follow-up colonoscopy after a positive stool test from 48% to 69%
A meta-analysis of 21 studies shows which nudges close the loop. Also: the 2026 BSR guideline on polymyalgia rheumatica, what treating low sodium before surgery did and did not change, and whether tight glucose control prevents neuropathy.
The edition in brief
Today's internal medicine edition closes on the abnormal stool test that never reaches colonoscopy. Across 21 studies and 19,613 patients, follow-up colonoscopy after a positive faecal immunochemical or occult blood test rose from a pooled 47.8% to 69.1% with interventions; patient navigation (RR 1.24), patient reminders (1.32), clinician reminders (1.36) and automated gastroenterology referral (1.68) were each associated with higher completion, though heterogeneity was often high. The 2026 British Society for Rheumatology guideline on polymyalgia rheumatica replaces the 2009 version, adding options for a faster steroid taper, early methotrexate, IL-6 receptor antagonists for those who cannot taper, and bone protection for everyone. In 24,803 surgical patients, a protocol of physician referral for preoperative sodium below 130 mmol/L made no difference to 30-day mortality, ICU admission or length of stay; a possible effect on one-year mortality may reflect treating the underlying disease. A meta-analysis of randomised trials found intensive glycaemic control made little or no difference to incident diabetic neuropathy (OR 0.93, 0.85 to 1.02). The pearl covers the speed limit for correcting chronic hyponatraemia.
BSR 2026 polymyalgia guideline: faster tapers, earlier steroid-sparing options
Plan steroid-sparing therapy and bone protection at diagnosis of polymyalgia, rather than waiting for relapses.
Referring surgical patients with sodium below 130 did not change 30-day outcomes
Treat preoperative sodium below 130 as a prompt to find the underlying cause, not as a number to correct quickly before theatre.
Tighter glucose control made little difference to new diabetic neuropathy
Do not rely on HbA1c to prevent neuropathy; examine the feet annually and treat the other risk factors too.
Chronic hyponatraemia has a speed limit
In chronic hyponatraemia, keep the rise to about 8 mmol/L in 24 hours and recheck sodium every four to six hours early on.
Navigation, reminders and auto-referral lifted colonoscopy after a positive stool test
Treat a positive stool test as unfinished until colonoscopy is done, and use automatic referral or reminders to get there.
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