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All obstetrics & gynaecology briefings

The edition · Obstetrics & Gynaecology

The sleep complaint that is not a hot flush

Insomnia in the menopausal transition has competition: obstructive sleep apnoea, restless legs and periodic limb movement all rise at the same time and none of them answers to oestrogen. Plus fetal brain growth on a changed diet, astaxanthin before oocyte retrieval, and the three numbers that predict survival after laser for twin-twin transfusion.

The edition in brief

Today's obstetrics and gynaecology desk opens with sleep in the menopausal transition. A narrative review covering literature from 2015 to March 2026 sets out four primary sleep disorders that become commoner across perimenopause and postmenopause - insomnia, obstructive sleep apnoea, restless legs syndrome and periodic limb movement disorder - and argues that reported prevalence depends heavily on menopausal stage, on whether vasomotor symptoms are present, and on whether sleep was measured by questionnaire or objectively. A randomised trial in Ecuador tested a locally adapted ancestral dietary pattern from 12 weeks' gestation to birth in 215 women. Fetal corpus callosum length was greater by 0.19 cm (95% CI 0.02 to 0.35) and gangliothalamic ovoid height by 0.15 cm (0.03 to 0.26) between 21 and 35 weeks, while femur length was shorter by 0.10 cm. A triple-blind pilot trial of astaxanthin 12 mg daily for six weeks before oocyte retrieval in 44 women with polycystic ovary syndrome found higher total and mature oocyte yields and better embryo quality after adjustment, with pregnancy outcomes numerically higher but not significant. A meta-analysis of 17 aromatherapy studies in 1,347 women reports improvement across vasomotor, psychological and sleep outcomes, with no effect on urogenital symptoms and GRADE certainty rated low or very low throughout. The edition closes on 915 fetoscopic laser procedures for twin-twin transfusion syndrome over 25 years: dual survival at six months was 65.2%, and three pre-procedure findings predicted dual demise - cervical length of 15 mm or less, abnormal donor umbilical artery Doppler, and earlier gestational age at intervention. All three are available before the woman is counselled.

In this edition
01Clinical update

Four sleep disorders rise at menopause, and only one of them is insomnia

Before treating menopausal insomnia, ask what wakes her and what she is like by day - apnoea and restless legs both rise at this stage and neither responds to hormone therapy.

2 min · Obstetrics and gynecologyRead →
02Research

A changed pregnancy diet moved fetal brain measurements, and femur length with it

Encourage dietary diversity in pregnancy on the strength of this, but do not tell a woman it will make her baby's brain develop better.

2 min · Proceedings of the National Academy of Sciences of the United States of AmericaRead →
03Research

Astaxanthin before retrieval: better embryos, no pregnancy signal yet

Not a reason to add astaxanthin to an IVF protocol, but a reasonable thing to know when a patient asks about it.

2 min · Human fertility (Cambridge, England)Read →
04Clinical update

Aromatherapy for menopausal symptoms: a large effect on weak evidence

No reason to discourage a woman already using aromatherapy, and no basis for offering it in place of treatment with real evidence behind it.

2 min · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and GynaecologyRead →
05Pearl

Ask who else is in the room

Ask what a bed partner has noticed before you accept insomnia as the diagnosis.

1 minRead →
06
Practice changer

Three numbers you already have before laser for twin-twin transfusion

Measure cervical length and check the donor umbilical artery Doppler before laser for twin-twin transfusion, and use both in the counselling rather than only in the operative note.

2 min · BJOG : an international journal of obstetrics and gynaecologyRead →
Primary outcome
Fetal or neonatal survival at six months
Effect
Dual survival 65.2%, single survivor 23.9%, dual demise 11%; cervical length 15 mm or less aOR 6.1 (95% CI 2.7-14.1); abnormal donor umbilical artery Doppler aOR 5.1 (1.7-15.6); aOR 1.2 (1.1-1.3) per earlier week

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