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The edition · Paediatrics

Egg allergy fell after guidelines moved egg into the first six months

Population data from Melbourne show egg allergy dropping after advice to introduce egg earlier, most in infants with eczema; a second skeletal survey still finds extra fractures in suspected abuse; and a simple prescribing alert kept short antibiotic courses for skin infections going for two years.

The edition in brief

Two population samples of 12-month-old infants in Melbourne, tested with skin prick and oral food challenge, showed egg allergy prevalence falling from 9.2% in 2007–2011 to 7.6% in 2018–2019 after guidelines recommended earlier egg introduction, with median age at introduction dropping from 8 to 6 months. In infants with early eczema, prevalence fell from 34.6% to 21.9%. A Welsh audit of 168 children under two investigated for suspected non-accidental injury found additional fractures on the follow-up skeletal survey in 7.1%, and one child's only fracture appeared on the second survey, supporting the two-survey protocol. A national US study of 36,552 paediatric sepsis episodes in publicly insured children found 3.9% 30-day mortality, with wide regional variation and lower mortality in regions with a children's hospital. The five-year FIREFISH extension found 90% of infants with type 1 spinal muscular atrophy alive on risdiplam, 80% without permanent ventilation, and 59% sitting unsupported. And a statewide paediatric network kept 88.5% of skin and soft-tissue infections on seven days or less of antibiotics for two years using a point-of-care alert.

In this edition
01
Clinical update

The second skeletal survey found extra fractures in 7% of children investigated for abuse

Do not skip the follow-up skeletal survey in children under two investigated for abuse — it found additional fractures in about 1 in 14.

2 min · Archives of disease in childhoodRead →
Primary outcome
Additional fractures detected on primary and secondary skeletal surveys
Effect
Primary 6.0%; secondary 7.1% additional; 0.6% fracture found only on secondary
02Research

Paediatric sepsis mortality varied up to several-fold between US regions

Paediatric sepsis outcomes depend on where a child is treated; build recognition and transfer pathways where paediatric expertise is thin.

1 min · PediatricsRead →
03Research

Five years of risdiplam: 80% of infants with type 1 SMA alive without permanent ventilation

Risdiplam kept most infants with type 1 SMA alive and off permanent ventilation for five years, but early diagnosis still matters most.

1 min · The Lancet. Child & adolescent healthRead →
04Research

A point-of-care alert kept short antibiotic courses for skin infections going for two years

Prescribe five to seven days of antibiotics for most uncomplicated paediatric skin infections, and use a system prompt to keep it that way.

1 min · PediatricsRead →
05Pearl

Introducing egg to an infant with eczema: practical steps

Introduce well-cooked egg at about six months and keep it in the diet, especially in infants with eczema.

1 minRead →
06
Practice changer

After earlier-egg guidelines, egg allergy fell from 9.2% to 7.6% — and from 35% to 22% in infants with eczema

Make early introduction of well-cooked egg at around six months routine advice, especially for infants with eczema.

2 min · JAMA pediatricsRead →
Primary outcome
Challenge-confirmed egg allergy prevalence
Effect
9.2% to 7.6% (−1.6 points, 95% CI −3.3 to −0.005); eczema 34.6% to 21.9%

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