Pathology
Mismatch repair staining is worth adding for three sarcoma types, a case series argues
Deficiency was found in about 1 in 20 uterine leiomyosarcomas and some pleomorphic sarcomas, with Lynch syndrome and immunotherapy at stake. A living guideline keeps salivary tests for oral cancer out of routine use, and self-collected swabs matched clinician samples for detecting CIN2+.
Nineteen breast pathologists agreed only moderately on phyllodes features, and training barely helped
Agreement on stromal cellularity, atypia and border in fibroepithelial lesions stayed moderate after structured training; most pancreatic acinar cell carcinomas carried homologous recombination defects; and long-read sequencing caught CYP21A2 carriers that standard assays miss.
Low-risk HPV in situ hybridisation flags digital papillary adenocarcinoma, if you look for dots
A commercial CISH assay separated every digital papillary adenocarcinoma from tubular adenoma; POU2F3-type biliary neuroendocrine carcinomas can lack standard neuroendocrine markers; GPNMB is sensitive but not specific for uterine PEComa; and a sequencing index settles clonality.
Time-zero biopsy should not decide alone whether a donor kidney is discarded
A 203-report meta-analysis finds every histology–outcome link of very low certainty, TNBC after neoadjuvant pembrolizumab needs reporting beyond pCR, and ISUP moves bladder post-treatment reporting towards a standard.
MTAP immunohistochemistry settles ambiguous sequencing calls; mismatch repair loss in upper GI cancers needs more than one test
A pan-cancer study shows MTAP IHC reclassifies heterozygous NGS calls as true deletions, light-chain mRNA ISH sorts the NLPHL-cHL grey zone, a DCIS algorithm aims to spare sentinel node biopsy, AI on H&E finds occult neck node deposits, and a real-world series maps why upper GI mismatch repair deficiency needs multimodal work-up.
MMR status in prostate cancer differed between foci in over half of multi-block cases
Mismatch repair deficiency sat in the highest-grade focus, so that is the block to stain; FOG1 marks gastro-oesophageal adenocarcinoma where CDX2 fails; nanopore methylation matched arrays at family level in paediatric CNS tumours; and a stepwise panel separates metaplastic breast carcinoma from cutaneous SCC.
In small-bowel NETs, only the Ki67 of the mesenteric deposit predicted progression — stain the deposit, not only the primary
A Histopathology cohort on where to grade jejunoileal NETs, evidence that MTAP loss does not stand in for CDKN2A deletion in peritoneal mesothelioma, a methylation triage meta-analysis for HPV-positive women, and a copy-number split within TP53-mutated multiple-classifier endometrial cancer.
A three-stain panel caught 89% of lung carcinoid relapses; the WHO classification caught 11%
On preoperative biopsies, OTP, CD44 and Ki-67 outperformed the WHO 2021 classification on prognosis and more than doubled inter-observer agreement. Folate receptor alpha helps separate serous tubal intraepithelial carcinoma from its mimics, and small cell carcinoma of the bladder splits into two phenotypes with different antibody-drug conjugate targets.