Clinical Pharmacology · page 2

FDA · EMA · CPT · Br J Clin Pharmacol · CPIC

Earlier editions

Tacrolimus after Paxlovid: withhold, then restart at 10% and step up over nine days

A Japanese pharmacokinetic model turns a known interaction into a restart schedule. Also: a structured adverse-effect check for older patients on many drugs, PCSK9 inhibitors in a signal search, CYP2D6 and metoprolol, and a premixed amiodarone recall.

6 findings · 6 min

22 Sep

One person in 330 carries a variant that turns an aminoglycoside into permanent deafness

A UK pharmacogenomics guideline sets out when to test MT-RNR1 before gentamicin or amikacin — and is explicit that a missing result must not delay treatment in sepsis. Rifampicin removes 99% of a CYP3A substrate's exposure, and Baxter's premixed GALAXY containers are under a Class II recall spanning amiodarone and vancomycin.

5 findings · 8 min