Depot antipsychotics in bipolar disorder were linked to about half the rate of manic admissions

The edition in brief

In 2,086 people with bipolar disorder in Hong Kong who had periods on both long-acting injectable and oral antipsychotics, injectable periods were associated with fewer psychiatric admissions (aIRR 0.67) and manic admissions (aIRR 0.51), with no rise in cardiovascular admissions. Extrapyramidal symptoms were about three times as likely in the first 90 days. A Berlin study of 70 patients after NMDA receptor encephalitis found two-thirds still had symptoms a median 22 months on, mostly memory problems, and psychiatric features shifted from psychosis to mood. In 62 weight-restored women with anorexia nervosa, measures of how accurately they sensed gut signals predicted relapse at six months, in a small experimental study. Serum and CSF ACE protein was lower in 122 young people with early psychosis than in controls, and lower again in treatment-resistant cases, a cross-sectional research finding. A meta-analysis of 15 trials suggested exercise may lower depressive symptoms in lung cancer, with very low certainty.