In healthy hands and feet, Doppler signal was rare at any age, but grey-scale findings were not

The edition in brief

An international OMERACT study scanned the hands, wrists and feet of 802 healthy adults aged 18 to 80. Doppler signal was minimal in every joint and age group, so Doppler in these joints is likely to be abnormal at any age; grey-scale findings were common, especially in the first and second metatarsophalangeal joints (45% and 39% had some finding), and normal thresholds for synovial hypertrophy and effusion varied by joint and age. A meta-analysis of 2,289 men with Klinefelter syndrome found very high odds of clinically manifest autoimmune disease (OR 48), mostly lupus, Sjögren's, systemic sclerosis, thyroid disease and type 1 diabetes, from a small, heterogeneous evidence base. In 108 patients given CAR-T for autoimmune disease, 80% had cytokine release syndrome, nearly all grade 1–2; higher baseline B-cell counts and IL-6 were associated with it. The pearl covers when to think of lupus in a man.