The edition · Anaesthesiology
An adductor canal catheter added nothing to a single shot with dexamethasone after knee replacement
A blinded TKA trial finds no 24–48 hour opioid saving from a 50-hour catheter; PUMA publishes extubation guidance built on 'at risk' assessment; antiemetic-dose steroids did not prevent pulmonary complications in the iPROVE trials; and femoral catheters did not beat adductor canal catheters after ACL repair.
The edition in brief
In a participant- and assessor-blinded trial of 94 primary total knee arthroplasties, all patients had iPACK, periarticular infiltration and oral multimodal analgesia. Adding a 50-hour continuous adductor canal ropivacaine infusion to a single-injection block did not reduce 24–48 hour opioid use compared with a single injection with 2 mg perineural dexamethasone (median 30 vs 38.8 mg; 95% CI of difference −22.5 to 7.0), and 7% of catheter patients had transient knee buckling. The Project for Universal Management of Airways has issued extubation guidelines: assess hypoxaemia, aspiration and airway-stimulation risk, and team and situational factors; treat planned extubation as elective and defer it when that lowers risk; and prefer conversion procedures over a continuous guide to replacement when extubation is 'at risk'. A weighted secondary analysis of 1,963 patients in two iPROVE trials found antiemetic-dose intraoperative corticosteroids were not associated with fewer postoperative pulmonary complications (OR 0.86, 0.62 to 1.18), despite a crude difference. A 60-patient double-blind trial after ACL reconstruction found continuous femoral nerve block was not superior to adductor canal block for 48-hour pain (−0.31 NRS points, −1.39 to 0.77).
PUMA extubation guidelines: decide whether extubation is 'at risk', then plan for it
Before every extubation, decide explicitly whether it is 'at risk', and for those that are, keep a continuous guide and a stated rescue plan — or defer.
Antiemetic-dose steroids were not linked to fewer pulmonary complications
Give dexamethasone for nausea, not for lung protection — antiemetic doses were not associated with fewer pulmonary complications.
Continuous femoral block was not superior to adductor canal block after ACL reconstruction
Use an adductor canal block for ACL reconstruction; a femoral catheter did not improve 48-hour pain and costs quadriceps strength.
Perineural dexamethasone lengthens a single shot without a catheter
Add 2 mg perineural dexamethasone to single-shot knee blocks and schedule oral analgesia ahead of block resolution.
A continuous adductor canal catheter did not beat a single shot with dexamethasone after TKA
For primary TKA with a full multimodal regimen, choose a single-shot adductor canal block with dexamethasone over a continuous catheter.
Read the rest in the app
You have read your two free briefings this month. The app carries all 27 specialties, every morning, free — and this one is waiting in it.

Scan to keep reading on your phone. No account needed to start.
Tomorrow morning, before your first patient
One edition a day for anaesthesiology, written by the desk, every claim tied to its paper. Six minutes.
Get the app — free