Routine CT coronary angiography after MI rule-out did not prevent MI or cardiac death

The edition in brief

TARGET-CTCA enrolled 3170 patients at 14 UK emergency departments in whom myocardial infarction had been ruled out but high-sensitivity troponin exceeded 5 ng/L, marking intermediate risk. Outpatient CT coronary angiography-guided care did not reduce myocardial infarction or cardiac death over a median three years (7.1% vs 7.3%, adjusted HR 0.95, 0.73 to 1.23). Routine CT after a negative rule-out is not supported; risk-factor treatment and clinical follow-up remain the priority. The EVER trial in five Korean ICUs found a structured six-step early mobilisation programme for ventilated patients with sepsis or respiratory failure did not improve function at ICU discharge or at 12 months, despite earlier and more mobilisation. A German trial of 103 paramedics and emergency clinicians found a 30-minute curated online video and podcast module improved recognition of high-risk ACS ECG patterns more than print materials (55% to 65.5% vs 57% to 60%). FDA lists a Class II recall of Baxter's premixed vasopressin 40 units in 100 mL for manufacturing-practice deviations.