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Pearl · 05 of 06

Ask when each drug was started, not just what the patient takes

Ask when each drug was started and what prompted it; sequence is the information a medication list omits and the only way to see a cascade.

A repeat prescription list is a snapshot with the causality removed. The single question that restores it is when did you start this one, and what was happening at the time. Sequence is what separates a treated comorbidity from a treated side effect, and it is not recorded anywhere on the list itself.

Three habits make it quick. Work backwards from the newest drug rather than reading the list top to bottom, because the newest is the likeliest to be treating something the older ones caused. For each drug added in the last two years, ask what symptom prompted it. And ask specifically about the drugs patients do not count as drugs - eye drops, inhalers, topical steroids, over-the-counter analgesics and supplements, which in India also means anything bought directly from a pharmacy without a prescription.

When the sequence reveals a cascade, the fix is usually to reconsider the first drug rather than to add anything. Stopping the second drug alone leaves the symptom, and the symptom brings the prescription back.

  • Read the list newest-first and ask what prompted each recent addition
  • Ask separately about eye drops, inhalers, topicals, analgesics and supplements
  • Write the start date next to each drug so the next clinician has the sequence
  • When a cascade is found, address the initiating drug rather than only stopping the second
  • Warn the patient that stopping the first drug should improve the symptom the second was treating - so they know what to expect

Why it matters

Without the sequence, a drug treating another drug's side effect is indistinguishable from a drug treating disease.

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