DailyDoctor Archive Specialties Get app
Back to the 26 September 2026 edition

Research · 03 of 06

A clinician's eyeball can rule out frailty before angiography, but not rule it in

Trust a "not frail" impression; confirm a "frail" impression with a formal tool before it changes management.

Design
Prospective observational diagnostic accuracy study
Population
200 patients aged ≥70 referred for coronary angiography
Primary outcome
Accuracy of eyeballing vs Fried frailty test
Effect
Sensitivity 93.9%, NPV 98.5%, specificity 80.8%, PPV 49.2%; AUC 0.87

This Israeli prospective study, published 17 September in the Journal of the American Geriatrics Society, assessed 200 patients aged 70 and over before coronary angiography. Two cardiologists, blinded to each other, rated frailty by the formal Fried test and by "eyeballing" on a Fried-like scale.

Frailty prevalence by Fried was 16.5%. Eyeballing had a sensitivity of 93.9% and negative predictive value of 98.5%, specificity of 80.8% and positive predictive value of 49.2% (AUC 0.87). Specificity was lower in women and inpatients. Frailty on the Fried test was associated with higher six-month mortality and readmission.

A quick clinical impression is good at spotting who is not frail. When the eyeball says frail, half the time it is wrong, and a structured measure should confirm before it changes a procedural decision.

  • A clinician's impression that an older patient is not frail is usually right.
  • When frailty is suspected by eye, confirm with a structured tool such as the Fried test.
  • Clinical impression over-called frailty more often in women and inpatients.
  • Frailty on formal testing predicted six-month death and readmission after angiography.

Why it matters

Supports a two-step approach that saves time without letting impressions decide access to procedures.

The statistics, in plain English

A positive predictive value of 49.2% means that about half of patients judged frail by eye were not frail on formal testing.

Read the rest in the app

You have read your two free briefings this month. The app carries all 27 specialties, every morning, free — and this finding is waiting in it.

QR code to install Daily Doctor
Get Daily Doctor — free

Scan to keep reading on your phone. No account needed to start.

healthyageingdementiadeliriumfrailtyfalls

Tomorrow morning, before your first patient

One edition a day for geriatrics, written by the desk, every claim tied to its paper. Six minutes.

Get the app — free
Daily Doctor All 27 specialties, every morning. Free.
Get the app