With local antibiotics in place, a week of systemic therapy matched four after bone infection surgery

The edition in brief

SOLARIO randomised 500 adults who had surgery for orthopaedic infection with an implanted local-antibiotic carrier to at most 7 days or at least 4 weeks of systemic antibiotics; definite treatment failure at 12 months was 11.1% vs 14.1% (risk difference −3.0 points, 95% CI −9.0 to 3.0), meeting non-inferiority, and treatment-related symptoms by week 6 fell from 45.2% to 17.2%. A JAMA systematic review of 69 studies published to June 2026 found influenza vaccines continued to be associated with fewer hospitalisations and deaths, with vaccine effectiveness of 80% against paediatric influenza deaths, a relative effectiveness of 43.6% for high-dose over standard-dose vaccine against hospitalisation in older adults, and no new safety signals including Guillain-Barré syndrome in almost 10 million vaccinees. A field evaluation of the Dragonfly point-of-care molecular test in 300 people with suspected mpox in Uganda showed 98.5% sensitivity and 96.2% specificity against laboratory PCR, with results in under 40 minutes. The FDA recorded a supplement to Sandoz's generic tigecycline application; this is an administrative action on an existing generic, not a new indication or safety finding.