Comorbidity amplifies heatstroke risk at a given temperature; fewer than one in seven with fatty liver and risky drinking got alcohol treatment

The edition in brief

A Japanese claims-based case-control study of 21,724 heatstroke cases and 65,172 matched controls found that the association between wet-bulb globe temperature and heatstroke was stronger with more chronic conditions: at 33°C against a reference of 25°C, the odds ratio was 2.04 with no conditions and 2.66 with four, after adjusting for heat-sensitive medicines. In a matched Colorado cohort of 100,140 people, cannabis use disorder was associated with higher all-cause mortality (HR 1.52, 1.30 to 1.77), mainly injury, overdose, accidents and cancer, but not cardiovascular or respiratory death; as an observational study, it cannot show causation. In US linked VA-Medicare data, PSA testing among men aged 80 and over was lower in VA primary care than in fee-for-service Medicare (IRR 0.70), suggesting testing tracked likelihood of benefit more closely there. In 608 adults with steatotic liver disease, 14.5% reported hazardous alcohol use and 39.1% mild-to-moderate use, yet only 13.4% of those with any alcohol use received treatment; treatment was associated with falling AUDIT-C scores. The pearl covers medicines that impair heat tolerance.