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Pearl · 05 of 06

Give thiamine before glucose in alcohol withdrawal

Start thiamine at the same time as, or before, any glucose in a patient with heavy alcohol use.

In anyone admitted with heavy alcohol use, give thiamine before or with intravenous glucose, because glucose can precipitate Wernicke encephalopathy in a thiamine-deficient patient. Confusion, ataxia and eye-movement abnormalities should prompt treatment without waiting for the full triad.

Check glucose, magnesium and potassium early, and reassess the withdrawal score at regular intervals rather than relying on a single assessment at admission.

  • Give thiamine before or with intravenous glucose
  • Treat suspected Wernicke encephalopathy without waiting for the full triad
  • Check glucose, magnesium and potassium early
  • Reassess the withdrawal score regularly through the admission

Why it matters

The sedative chosen matters less than missing a treatable cause of confusion.

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