In a patient with nephrotic syndrome and a positive anti-PLA2R antibody, the titre does more than make the diagnosis. Measure it at baseline and every three to six months. Falling titres precede falling proteinuria by months, so immunological remission is the early sign treatment is working.
A persistently high titre at six months suggests treatment failure even if proteinuria is still settling. A rising titre after remission warns of relapse before proteinuria returns.
- Baseline anti-PLA2R titre at diagnosis.
- Repeat every 3–6 months during treatment.
- Titre falls first; proteinuria follows.
- Rising titre after remission predicts relapse.
Why it matters
Titres let you judge treatment months earlier than proteinuria alone.
Read the rest in the app
You have read your two free briefings this month. The app carries all 27 specialties, every morning, free — and this finding is waiting in it.
Scan to keep reading on your phone. No account needed to start.
Tomorrow morning, before your first patient
One edition a day for nephrology, written by the desk, every claim tied to its paper. Six minutes.
Get the app — free