A low NIHSS score can hide a proximal occlusion held at bay by collaterals. These patients may look well on arrival and then deteriorate over hours as collaterals fail. A low score is a reason to image the vessels, not a reason to skip it.
Cortical signs out of proportion to the score — aphasia, neglect, gaze preference, visual field loss — are the clues, and fluctuation is a warning.
- Do CT or MR angiography in every suspected acute ischaemic stroke that could be a reperfusion candidate, whatever the NIHSS.
- Look for cortical signs such as aphasia, neglect or gaze deviation even when the total score is low.
- Repeat the NIHSS frequently in the first 24 hours; early worsening calls for urgent reassessment.
- Discuss proven large-vessel occlusion with a thrombectomy centre early rather than after deterioration.
Why it matters
Patients with mild deficits and proximal occlusions are the ones most likely to worsen unexpectedly.
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