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Pearl · 04 of 05

The 'mild' stroke with a large-vessel occlusion is not mild

Image the vessels in every potential reperfusion candidate; a low NIHSS does not rule out a large-vessel occlusion.

A low NIHSS score can hide a proximal occlusion held at bay by collaterals. These patients may look well on arrival and then deteriorate over hours as collaterals fail. A low score is a reason to image the vessels, not a reason to skip it.

Cortical signs out of proportion to the score — aphasia, neglect, gaze preference, visual field loss — are the clues, and fluctuation is a warning.

  • Do CT or MR angiography in every suspected acute ischaemic stroke that could be a reperfusion candidate, whatever the NIHSS.
  • Look for cortical signs such as aphasia, neglect or gaze deviation even when the total score is low.
  • Repeat the NIHSS frequently in the first 24 hours; early worsening calls for urgent reassessment.
  • Discuss proven large-vessel occlusion with a thrombectomy centre early rather than after deterioration.

Why it matters

Patients with mild deficits and proximal occlusions are the ones most likely to worsen unexpectedly.

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