DailyDoctor Archive Specialties Get app
Back to the 23 October 2026 edition

Research · 02 of 06

Liposomal bupivacaine I-TAP block reduced opioid use after caesarean

Consider the I-TAP approach a promising refinement of truncal blocks after caesarean, pending replication.

Design
Single-centre, three-arm randomised controlled trial
Population
150 healthy women having elective caesarean under combined spinal-epidural
Primary outcome
24-hour intravenous sufentanil consumption
Effect
I-TAP vs TAP −11.4 µg (95% CI −17.6 to −5.3); vs sham −23.2 µg (−29.4 to −17.1)

A single-centre Chinese trial randomised 150 women having elective caesarean under combined spinal-epidural anaesthesia to an ultrasound-guided ilioinguinal-transversus abdominis plane (I-TAP) block, a conventional TAP block, or a sham block. Both active blocks used 266 mg liposomal bupivacaine with 50 mg plain bupivacaine in 60 mL. All groups also received epidural hydromorphone.

At 24 hours, the I-TAP group used 11.4 µg less intravenous sufentanil than the TAP group (95% CI −17.6 to −5.3), a 37% reduction, and 23.2 µg less than sham. The difference held at 48 hours, with better pain scores, quality-of-recovery scores and satisfaction, and no excess adverse events.

The rationale is anatomical: a standard TAP block can miss the L1 dermatome that a Pfannenstiel incision crosses. The I-TAP approach is designed to cover it.

This is one centre, and sufentanil consumption is a surrogate for what matters to the mother. Liposomal bupivacaine is costly and not widely stocked in Indian hospitals; whether plain bupivacaine in the same plane gives a similar gain is not tested here.

  • Discuss with your anaesthetic team whether TAP blocks after caesarean reliably cover the L1 dermatome.
  • Treat this as one single-centre trial, not yet a reason to change a working protocol.
  • Check whether liposomal bupivacaine is available and affordable before considering the technique.
  • Keep neuraxial opioid as the foundation of post-caesarean analgesia — every group here had it.

Why it matters

It suggests some post-caesarean pain persists because standard TAP blocks miss the incision's nerve supply.

The statistics, in plain English

The confidence interval of −17.6 to −5.3 µg does not cross zero, so the I-TAP group very likely used less opioid. Whether 11 µg of sufentanil over a day is clinically important is a separate question — the better pain and recovery scores suggest it may be.

Read the rest in the app

You have read your two free briefings this month. The app carries all 27 specialties, every morning, free — and this finding is waiting in it.

QR code to install Daily Doctor
Get Daily Doctor — free

Scan to keep reading on your phone. No account needed to start.

maternallabourpreterm

Tomorrow morning, before your first patient

One edition a day for obstetrics & gynaecology, written by the desk, every claim tied to its paper. Six minutes.

Get the app — free
Daily Doctor All 27 specialties, every morning. Free.
Get the app