C3F8 came out worst on vision in 7,466 retinal detachment repairs

The edition in brief

BEAVRS-EURETINA registry data from 2012 to 2024 gave 7,466 eyes for anatomical and 5,734 for visual analysis after repair of low-to-moderate complexity rhegmatogenous retinal detachment, comparing SF6, C2F6 and C3F8 with propensity matching. C2F6 and SF6 gave similar acuity (mean difference -0.01 logMAR). C3F8 was associated with worse acuity than both C2F6 (0.10 logMAR worse, 95% CI 0.07 to 0.14) and SF6 (0.09 worse, 0.04 to 0.13), more cystoid macular oedema than SF6 (OR 2.72, 1.13 to 6.57) and more raised pressure than C2F6 (OR 0.41 for C2F6 versus C3F8). Anatomical estimates favoured C2F6 without reaching clear significance against SF6. In 1,223 eyes of 775 children operated for primary congenital glaucoma, cup-disc ratio reversed by at least 0.2 in 528 eyes (43.2%); each additional millimetre of baseline corneal diameter halved the odds of reversal (aOR 0.50, 0.42 to 0.59), and neonatal or infantile onset roughly doubled them. In 180 eyes followed a mean 5.1 years, OCT angiography vessel density detected progression a mean 2.3 years before the visual field (95% CI 1.3 to 3.2) against 1.5 years for nerve fibre layer thickness, with specificity 68.9% versus 75.6%. And in 10,819 eyes assessed before cataract surgery, routine undilated macular OCT had sensitivity 80% and specificity 95% against fundus examination but altered the plan in only 0.7% of eyes.