Ophthalmology
Pseudoexfoliation, raised pressure and family history predicted new glaucoma over 12 years
A Greek population cohort confirms who to watch most closely. Real-world pegcetacoplan slowed geographic atrophy growth by about 41% while vision still declined, and a third of blindness in Jammu's blind schools was avoidable.
Cefuroxime resistance in post-cataract endophthalmitis rose from a quarter to two-thirds of isolates
A French 23-year comparison found more enterococci and far more methicillin and cefuroxime resistance; vitrectomised eyes carried nearly four times the risk of cystoid macular oedema after cataract surgery; and anti-VEGF for ROP showed no neurodevelopmental penalty in the studies available.
Half of regressed polypoidal choroidal vasculopathy recurs within two years of stopping injections
A Thai prospective study tests as-needed aflibercept after complete polyp regression; the organism predicts the course of endogenous endophthalmitis, with Serratia most likely to cost the eye; and switching biologic class may beat a second anti-TNF in refractory uveitis.
For straightforward retinal detachment, C3F8 bought no extra reattachment and cost vision
A 7,466-eye registry comparison favours SF6 or C2F6 over C3F8, pre-eclampsia was associated with four times the hazard of postpartum glaucoma in glaucoma suspects, and a quantitative map makes ROP zoning reproducible.
Cataract surgery in outreach camps gave worse vision than fixed facilities across 61 countries; retinal detachment after anti-VEGF is about 1 in 8,700 injections
Pooled RAAB surveys of 41,881 operated eyes show a persistent outcome gap for camp surgery, a meta-analysis puts a number on post-injection detachment for consent, and trials report on conbercept for branch vein occlusion, early pegcetacoplan for geographic atrophy, and HOTV versus tumbling E for preschool screening.
HER2 antibody-drug conjugates damaged the ocular surface in 18 of 21 patients within a month
A prospective study describes vortex keratopathy and corneal nerve loss with HER2-targeted ADCs; half of endothelial grafts fail by three years after a tube shunt; a 17-million-procedure registry sets endophthalmitis rates by operation; glaucoma suspect follow-up can be risk-stratified; and Diwali firecracker injuries remain mostly in children.
After a failed trabeculectomy, repeat trabeculectomy slowed field loss at least as well as an Ahmed valve — and peak pressure predicted who progressed
A 186-eye cohort backs redo trabeculectomy, a meta-analysis finds less post-keratoplasty glaucoma after DMEK than DSAEK, cheap anti-inflammatories track with less sight-threatening diabetic retinopathy, intra-arterial chemotherapy saves more cT3b/c retinoblastoma eyes, and VR defocus training slowed axial growth a little.
Prostaglandin analogues and macular oedema after endothelial cell injection
A quarter of eyes developed cystoid macular oedema after cultured endothelial cell therapy, and 60 per cent of those were on a prostaglandin. Plus what fundus vasculometry adds to glaucoma prognosis, and the price of mini-monovision with an extended depth of focus lens.
Pegcetacoplan slowed atrophy by 41% over two years, and acuity still fell
A real-world two-year series on geographic atrophy, consensus definitions that separate leakage from true retinal vasculitis, rising paediatric uveitis, a drop for dim-light vision, and the case for operating on lamellar holes with epiretinal proliferation.
A vitrectomised eye has nearly four times the risk of cystoid macular oedema after cataract surgery
Seven thousand matched pairs, and the excess survives every subgroup and every exclusion the authors tried. Plus the Academy's verdict on anti-VEGF and neurodevelopment in retinopathy of prematurity, what 'unspecified glaucoma' actually contains, and two canal-based MIGS procedures that come out level.
Cefuroxime resistance in postcataract endophthalmitis has gone from a quarter to two-thirds
Two French centres compared 23 years of isolates: coagulase-negative staphylococci down, Enterococcus faecalis up fivefold, and methicillin resistance among staphylococci from 30% to 75%. Plus what happens when you defer treatment after polypoidal regression, switching biologics in refractory uveitis, and an FDA supplement for a ranibizumab biosimilar.
C3F8 came out worst on vision in 7,466 retinal detachment repairs
Registry data favour C2F6 and SF6 over perfluoropropane for routine detachment, cupping reversed in 43% of congenital glaucoma eyes after surgery, OCT angiography detected glaucoma progression 2.3 years before the field, and routine pre-cataract macular OCT changed 0.7% of plans.
For children under 8, the HOTV chart cut vision screening referrals and caught more true problems than tumbling E
A head-to-head comparison of screening charts in 995 children closes the edition. Before it: poorer cataract outcomes from outreach camps across 61 countries, aflibercept 8 mg against faricimab in vein occlusion, four years of pegcetacoplan, and depot triamcinolone after phaco.
Aspherical lenslet spectacles cut myopia progression by 71% in US children over two years
A double-masked trial extends HAL lens evidence beyond Asian children; ahead of Diwali, a prospective Indian series counts the cost of firecracker eye injuries; and the retinal detachment risk after an anti-VEGF injection is about 1 in 8,700.
Peak pressure, not mean pressure, is what the field follows
A repeat trabeculectomy cohort finds the postoperative pressure spike predicts field loss where the average does not; three ordinary anti-inflammatory drugs track lower rates of sight-threatening retinopathy; and only half of grafts survive three years in an eye with a drainage device.
Two diseases with one name, and only one is an emergency
A joint ophthalmology and internal medicine consensus on anterior ischaemic optic neuropathy sets out the split that decides everything: the arteritic form, which needs treatment the same day, and the far commoner non-arteritic form, for which nothing specific works. Plus mini-monovision with an extended-depth-of-field lens, macular oedema after endothelial cell injection, ray-tracing LASIK at a year, and the vision measurement that tracked cognition.
Atrophy slowed 41% and acuity fell anyway, and two OCT machines that disagree by 65 microns
Two years of real-world pegcetacoplan; a drusen phenotype that predicts which retina loses function; a new EFEMP1 variant causing night blindness rather than central drusen; and a reminder that choroidal thickness is not comparable across devices.
One endophthalmitis in 106 open globes, and a marker that says who to watch closely
Seventeen million procedures give per-operation infection rates worth quoting at consent; microvasculature dropout separates preperimetric eyes that will convert from those that will not; and melanoma carries six times the uveitis risk of lung cancer on checkpoint inhibitors.
Cefuroxime resistance has more than doubled in postcataract endophthalmitis
Two French tertiary centres tracked the organisms causing acute endophthalmitis across 23 years and found two-thirds of isolates now resistant to the drug most surgeons instil at the end of the case; plus how eight US centres treat endogenous fungal disease, and what the neurodevelopment evidence really says about anti-VEGF for retinopathy of prematurity.
Saving the eye in advanced retinoblastoma, and the corneas oncology is quietly damaging
Intra-arterial chemotherapy salvages cT3b and cT3c eyes without costing survival, a HER2 antibody-drug conjugate strips the tear film and the subbasal nerve plexus within six weeks, and eight modern lens formulas are ranked in eyes longer than 32 mm.
Three-quarters of healthy eyes have a red patch on the ganglion cell map
In 194 normal eyes, false positives on OCT deviation maps were the rule rather than the exception, and they got worse as the eye got longer. Also: myopic globes remodel in shapes that predict damage better than axial length, a reference map that fixes ROP zoning, and a very large NSAID cohort that proves less than it looks.
Two years of warning before the visual field moves
OCT angiography flagged glaucoma progression a mean 2.3 years before perimetry did, at some cost in specificity; four years of pegcetacoplan preserved about three times more retinal tissue when started early; and a third of the children in two Jammu blind schools were blind from avoidable causes.
SGLT2 inhibitors were linked to less retinopathy progression across 1.8 million patients
A meta-analysis of 16 studies found a 23% lower relative risk of diabetic retinopathy progression with SGLT2 inhibitors than with other glucose-lowering drugs, the ESCRS has published cataract surgery guidelines answering 32 clinical questions, and pooled data put rhegmatogenous detachment after anti-VEGF injection at 1 in 8,675.
SGLT2 inhibitors are linked to slower diabetic retinopathy progression
A meta-analysis of 1.8 million patients ties SGLT2 inhibitors to about a quarter less diabetic retinopathy and macular oedema progression, a combination-injection trial for DME trades fewer injections for steroid side effects, and a huge series puts a real number on retinal detachment risk after anti-VEGF.
SGLT2 inhibitors are associated with slower diabetic retinopathy progression
A meta-analysis of 1.8 million patients links SGLT2 inhibitors to less retinopathy and macular oedema progression than other glucose-lowering drugs, adding a dexamethasone implant to aflibercept clears oedema faster without improving vision, and a glaucoma drop is recalled for a container that will not deliver a drop.