C3F8 gas linked to worse vision than SF6 or C2F6 after routine retinal detachment repair

The edition in brief

In propensity-matched data from a European vitreoretinal registry covering 7,466 low-to-moderate complexity retinal detachments, C3F8 gas was associated with worse postoperative acuity than C2F6 or SF6 (about 0.1 logMAR, one line), more cystoid macular oedema than SF6 and more raised pressure than C2F6, without better anatomical success. C2F6 may have a small anatomical edge. A meta-analysis of 25 studies found biosimilar anti-VEGF agents matched reference ranibizumab and aflibercept for vision, retinal thickness and adverse events over up to about 64 weeks, with moderate-to-high certainty; this is directly relevant where cost limits treatment. Paracentral acute middle maculopathy on OCT was seen in 28% of 80 patients with biopsy-proven giant cell arteritis and in none of 179 with non-arteritic ischaemic optic neuropathy, including some without visual symptoms. An Indian randomised trial of 100 eyes found a single subconjunctival triamcinolone injection controlled post-phaco inflammation as well as six weeks of prednisolone drops, with more subconjunctival haemorrhage. Another Indian trial in 80 eyes with diabetic retinopathy found a lower infusion pressure during phaco was associated with better macular and disc perfusion on OCT angiography.