The edition · Paediatrics
Short antibiotic courses for childhood pneumonia and sinusitis rose from 13% to 65% with a pathway and prompts
A US paediatric emergency department improvement project shows how guideline durations get adopted, without more return visits. Also: levetiracetam against valproate in childhood epilepsy, and a consensus on recognising dysfunctional breathing.
The edition in brief
A quality improvement project in Pediatrics, published on 13 October, raised the share of children discharged from one US paediatric emergency department with community-acquired pneumonia or acute bacterial sinusitis on a guideline-recommended short antibiotic course from 13.1% to 64.8%. The tools were a clinical pathway, electronic record changes, prescriber education and feedback. Return visits within 14 days did not rise. Current guidance supports 3 to 5 days for uncomplicated pneumonia and 5 to 7 days for sinusitis. A meta-analysis of eight randomised trials and 1,000 children found no significant difference in seizure freedom between levetiracetam and valproate (RR 0.95, 95% CI 0.83 to 1.09), with low-certainty evidence; levetiracetam had fewer adverse events and less weight gain. Time-to-event outcomes favoured valproate but were exploratory. A UK eDelphi of paediatric respiratory experts agreed ten clinical features consistent with dysfunctional breathing in children and young people, a first step towards a validated assessment tool. The pearl covers telling dysfunctional breathing from asthma.
Levetiracetam and valproate gave similar seizure freedom in children, with fewer side effects on levetiracetam
Levetiracetam and valproate performed similarly for seizure freedom in children; choose by syndrome, sex and side effects.
UK experts agree the features of dysfunctional breathing in children, but not its name
Consider dysfunctional breathing when a child's breathlessness does not match objective findings, before stepping up asthma treatment.
Breathless child, normal saturation and no wheeze: think beyond asthma
Confirm asthma objectively before escalating treatment in a breathless child with normal findings.
Short antibiotic courses for childhood pneumonia and sinusitis: from 13% to 65% without more returns
Use 3 to 5 days for uncomplicated childhood pneumonia and 5 to 7 days for sinusitis, and change the order-set default to make it stick.
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