A three-marker panel on lung carcinoid biopsies flagged 17 of 19 later relapses; WHO grading flagged 2

The edition in brief

In 98 Dutch patients with resected lung carcinoids, an immunohistochemical panel on the preoperative biopsy (OTP, CD44 and Ki-67) classed 17 of 19 later relapses as high risk, against 2 of 19 by WHO subtyping on biopsy. Negative predictive value was 0.96 versus 0.82, and interobserver agreement was higher (kappa 0.67 vs 0.28). In 408 tubal epithelial samples, high folate receptor alpha expression was seen in 73% of STICs and 77% of high-grade serous carcinomas but was uncommon in STIL and earlier lesions, suggesting an adjunct to p53 and Ki-67. In 79 bladder small cell carcinomas, transcription-factor staining separated high- and low-neuroendocrine groups with different DLL3, SLFN11 and Nectin-4 profiles. High MET expression in 112 pancreatic NETs was associated with adverse features and shorter survival. In 352 people with newly diagnosed myeloma, serum soluble BCMA predicted early treatment failure better than imaging or marrow tumour volume. All are retrospective or cross-sectional.