In small-bowel NETs, the mesenteric deposit's Ki67 predicted progression; the primary's did not

The edition in brief

In 75 jejunoileal well-differentiated neuroendocrine tumours with nodal or mesenteric spread, Ki67 measured in the largest mesenteric tumour deposit was the only index independently associated with progression (HR 1.22 per 1% increase); primary-tumour and nodal Ki67 were not, and in 68% of cases a node or deposit had a higher index than the primary. Korean consensus guidelines set out 15 recommendations for ctDNA testing on pleural effusion and bronchoalveolar lavage fluid in lung cancer, covering pre-analytical handling, validation and reporting; evidence is mostly from pleural fluid and only 21% of surveyed laboratories offered the test. In peritoneal mesothelioma, MTAP immunohistochemistry matched MTAP FISH well but agreed poorly with CDKN2A deletion (kappa 0.21), unlike pleural mesothelioma, so MTAP loss should be interpreted on its own rather than as a CDKN2A proxy at that site. Shallow whole-genome sequencing split 33 TP53-mutated multiple-classifier endometrial carcinomas into copy-number-high tumours, which carried all recurrences, and copy-number-low tumours with none. The pearl: apply the endometrial molecular classification in its fixed order.