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Pearl · 04 of 05

Taper long-term benzodiazepines; never stop them abruptly

Taper long-term benzodiazepines gradually over weeks to months with a written plan; abrupt cessation risks seizures.

After weeks to months of regular benzodiazepine use, stopping suddenly can cause rebound anxiety, insomnia, and in more severe cases withdrawal seizures or delirium. The established approach is a gradual, planned taper over weeks to months, agreed with the patient, with slower steps towards the end, when withdrawal symptoms are often most troublesome. Switching to a longer-acting agent such as diazepam before tapering is a common strategy. Pair the taper with support for the underlying anxiety or insomnia, for example CBT.

  • Agree a written taper plan with the patient before starting, with reductions every few weeks.
  • Slow the taper towards the end, when withdrawal symptoms are often worst.
  • Consider switching to an equivalent dose of a longer-acting benzodiazepine before tapering.
  • Offer CBT or other support for the underlying anxiety or insomnia during the taper.
  • Warn patients and families that abrupt stopping after long-term use can cause seizures.

Why it matters

Falling prescribing rates mean more clinicians will be withdrawing benzodiazepines, and how it is done determines whether it works.

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