Lithium prophylaxis was linked to half the postpartum recurrence rate in bipolar disorder

The edition in brief

Across eight observational studies of 554 women with bipolar disorder, postpartum recurrence was 21% (95% CI 15-29%) in those taking lithium prophylaxis and 41% (33-50%) in those who were not. Confounding by indication limits how far that can be read as a treatment effect, but it supports planning prophylaxis before delivery rather than after the first relapse. In a randomised trial of 184 outpatients with schizophrenia, adding early auditory processing training to cognitive remediation did not improve cognitive or functional outcomes, even in those with auditory deficits; cognitive remediation itself produced moderate gains across both arms. A small fMRI trial of Mindfulness-Oriented Recovery Enhancement in inpatients with opioid use disorder found changes in prefrontal responses to drug cues and longer abstinence at about four months than supportive therapy, with a small effect size in a subset of 38. In the US, a Class II recall covers one buprenorphine hydrochloride 0.3 mg/mL injection for crystallisation.