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Research · 03 of 05

Breast cancer risk models: the panel's problem is not the models, it is the disagreement between societies

Breast cancer risk models are only useful where a department has decided who runs them, at what threshold they act, and who talks to the patient — the panel's practical framework is aimed at exactly that gap.

An AJR expert panel has reviewed breast cancer risk stratification — the models in current clinical use, what the professional societies say about using them, and what stops the calculated number turning into a screening decision. Their framing of the problem is the useful part: societal recommendations vary, so there is no settled answer on which tool to use, when in a woman's life to run it, or what threshold should change her screening.

The panel proposes a practical stepwise approach to embedding risk assessment in routine work, and reviews the evidence for deep learning models that estimate risk from the mammogram itself rather than from a questionnaire. That last strand is genuinely different in kind: a model reading the image needs no family history to be collected, which is the step that fails most often in a busy service.

For a radiology department the decision is not which model is best but whether risk assessment happens at all and who owns it. A risk figure calculated and never acted on is worse than none, because it creates a record of a risk nobody addressed. Decide who runs the model, at what visit, what threshold triggers supplemental MRI or earlier screening, and who has the conversation — before adopting a tool. In Indian practice the constraint is different again: screening is largely opportunistic, family history data are thin, and the models in widest use were derived in Western populations, so a calculated risk should be treated as one input to a discussion rather than as a number to act on mechanically.

  • Decide who runs the risk model and at which visit before adopting one.
  • Set the local threshold that triggers supplemental imaging, and write it down.
  • Do not record a risk score with no pathway attached to it.
  • Check the derivation population of any model before applying it to Indian women.
  • Image-based risk models avoid the family history step that most often fails in practice.

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