The edition · General Surgery
Gastrojejunostomy configuration did not change delayed gastric emptying after Whipple
A French randomised trial found side-to-side and end-to-side reconstructions performed alike. Also: bailouts and costs with robotic cholecystectomy for acute cholecystitis, where trauma deaths now happen, and a single TXA bolus.
The edition in brief
The IPAD trial randomised 158 patients undergoing pancreatoduodenectomy at two French high-volume centres to side-to-side or end-to-side gastrojejunostomy. Delayed gastric emptying occurred in 38.0% and 30.4% respectively (RR 1.25, 95% CI 0.81–1.94), with no differences in fistula, reintervention, mortality, nutrition or quality of life at 90 days. Surgeons can use whichever configuration they do well. In 384,617 US emergency cholecystectomies for acute cholecystitis, the robotic approach was associated with slightly more bailouts — more conversions and subtotal cholecystectomies, fewer cholecystostomy tubes — the same bile duct injury rate and higher one-year costs. Among 497 trauma deaths attended by London's Air Ambulance, 77% occurred before hospital, a median 12 minutes after injury, and almost all haemorrhage deaths were prehospital. A Korean single-centre matched cohort found no mortality difference between a 1 g tranexamic acid bolus alone and bolus plus infusion. The pearl: when the critical view of safety cannot be achieved, a bailout is the safe operation, not a failure.
Robotic cholecystectomy for acute cholecystitis: more bailouts, same bile duct injury, higher cost
Laparoscopic cholecystectomy remains the sensible default for acute cholecystitis; robotic surgery adds cost without reducing bile duct injury.
Most trauma deaths in a mature system happen before hospital
Put effort into prehospital haemorrhage control, where most preventable trauma deaths now occur.
A single tranexamic acid bolus in trauma: no mortality difference in a matched cohort
Give the tranexamic acid bolus early; keep the infusion in protocol until a trial says otherwise.
No critical view of safety, no clipping
If the critical view of safety cannot be achieved, bail out rather than clip.
Side-to-side or end-to-side gastrojejunostomy after Whipple: no difference
Stop expecting gastrojejunostomy configuration to prevent delayed gastric emptying after pancreatoduodenectomy.
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