The AUA/SUO Advanced Prostate Cancer Guideline has been amended for 2026, incorporating evidence published since the 2023 version through the association's update process. Part I covers biochemically recurrent disease after local therapy is exhausted, and metastatic hormone-sensitive prostate cancer.
The amendment updates three areas the guideline panel singled out: imaging, germline and somatic testing, and the evaluation and treatment of these disease states. The direction of travel in this space — molecular imaging and genetic testing informing systemic treatment intensification — is reflected in the revised statements.
For a urologist, the practical step is to work from the amended guideline rather than the 2023 version when staging and treating advanced disease, and to read the full statements for the specific imaging and testing recommendations before updating local pathways. The panel notes this area is evolving and will need further review.
- The AUA/SUO advanced prostate cancer guideline was amended for 2026, updating the 2023 version.
- Part I addresses biochemically recurrent and metastatic hormone-sensitive prostate cancer.
- Updated areas are imaging, germline and somatic testing, and evaluation and treatment.
- Work from the amended guideline when staging and treating advanced disease.
- Read the full statements for specific imaging and testing recommendations before changing pathways.
Why it matters
Imaging and genetic testing are reshaping how advanced prostate cancer is staged and treated, and the guideline a clinician works from determines that pathway.
Don't overread it
This is a guideline amendment consolidating evidence, not a single new trial; the specific recommendation changes sit in the full document.
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