Psoriasis was linked to more liver and lung disease in 320,000 patients

The edition in brief

A UK cohort compared 320,220 people with psoriasis with 1.7 million matched controls across 225 groups of hospital-recorded diagnoses. Beyond the skin, psoriasis was associated with liver disease (HR 1.47), substance misuse including alcohol and tobacco (HR 1.26) and interstitial lung disease (HR 1.33), after adjustment for alcohol, smoking, weight and deprivation; the authors frame these as hypothesis-generating associations. A single-centre laboratory study of 100 bullous pemphigoid sera found an ELISA against the LABD97 fragment of BP180 detected 87% of cases, against 66% for the standard BP180 NC16A test and 52% for BP230, and picked up 83% of sera negative on both. In 277 patients with advanced mycosis fungoides or Sézary syndrome, a four-factor prognostic index separated median progression-free survival from 4.6 years to 0.9 years. A feasibility study of AI-assisted line-field optical coherence tomography found subclinical basal cell carcinomas on normal-looking facial skin in 9.3% of high-risk inpatients. A JAAD review sets out how to choose systemic psoriasis therapy around a patient's inflammatory comorbidities and cancer history.