- Design
- retrospective single-centre cohort with multivariable logistic regression
- Population
- 487 adults with unilateral idiopathic sudden sensorineural hearing loss, 2012 to 2019
- Primary outcome
- complete hearing recovery by initial audiogram configuration
- Effect
- complete recovery 50.0% ascending, 25.2% flat, 9.8% descending, 0% total-deaf; descending OR 0.25 (0.15–0.42), total-deaf OR 0.05 (0.01–0.22); AUC 0.78
Adults with unilateral idiopathic sudden sensorineural hearing loss treated at one tertiary centre between 2012 and 2019 were categorised by the configuration of their initial pure tone audiogram — ascending, flat, descending or total-deaf — and followed for complete recovery.
Among 487 patients, 80 (16.4 per cent) recovered completely. The split by configuration was stark: 50.0 per cent of the ascending group, 25.2 per cent flat, 9.8 per cent descending, and none of the total-deaf group. On multivariable analysis, descending (OR 0.25, 95% CI 0.15 to 0.42) and total-deaf (OR 0.05, 0.01 to 0.22) configurations independently predicted failure to recover, alongside older age and worse initial pure tone average. The model reached an AUC of 0.78.
None of this changes what you give — steroids remain the treatment — but it changes what you say. A patient with an ascending loss has a coin-flip chance of full recovery; one with a total-deaf audiogram, on this cohort, had none. That difference should shape the counselling at the first visit, the urgency of intratympanic rescue, and how early the conversation about hearing rehabilitation begins.
- Classify the configuration on the first audiogram and record it
- Counsel prognosis by configuration rather than giving one recovery figure to everyone
- Escalate to intratympanic treatment earlier in descending and total-deaf patterns
- Start the hearing rehabilitation conversation early where the configuration is unfavourable
- Do not promise recovery on the basis of prompt presentation alone
Why it matters
It gives the first consultation a prognosis to work with, where most units currently quote one average number.
Don't overread it
A single-centre retrospective cohort — the configuration predicts outcome, it does not tell you which treatment to choose.
The statistics, in plain English
An AUC of 0.78 is reasonable discrimination for a prognostic model but not enough to predict an individual: the ascending group's 50 per cent recovery rate rests on only 24 patients, about 4.9 per cent of the cohort. The zero per cent recovery in the total-deaf group is a small-sample zero, not a guarantee.
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