Prostate cancer in germline variant carriers looked more aggressive on MRI

The edition in brief

In a single-centre case-control study, 62 men with prostate cancer and a germline pathogenic variant were compared with 246 controls. Positive MRI (PI-RADS 3 or more) was similar (98% vs 96%), but carriers were more likely to have a PI-RADS 5 lesion (OR 2.7, 95% CI 1.5 to 4.9) and grade 3 extraprostatic extension (OR 3.0, 1.5 to 5.8), and more were upgraded at prostatectomy (37% vs 20%). A 64-patient retrospective study found higher FAPI-42 PET uptake in colorectal cancers with intermediate or high-grade tumour budding (SUVmax 12.66 vs 10.16); a model with body mass index had an AUC of 0.841 and needs external validation. A retrospective comparison of 92 liver procedures found 3D effective dose 4.1-fold lower with angio-CT than cone-beam CT, but total dose differences were not significant after uncertainty correction (p = 0.053). A Radiographics review argues that CT colonography is accurate and underused for colorectal cancer screening.